BIO 371 -- CELL BIOLOGY
Fall 2002, Tentative Schedule

Dr. Velinda Locklear Woriax --- Office S202 --- Office Hours as posted
Phone: 521-6567 (voice mail) or 521-6245 (secretary -- Helen Alston)
E-mail: velinda.woriax@uncp.edu http://courses.uncp.edu

Course Description & Goal: The aim of Bio 371 Cell Biology is to acquaint undergraduate students with the basic principles of cellular structure, organization, function, and behavior. The students will be introduced to the fundamental principles that guide cellular organization and operation as well as an introduction to crucial scientific evidence that has lead to the formulation of these central concepts.

Course Objectives: To familiarize the student with fundamental scientific knowledge concerning various topics in the discipline of cell biology. Examples of topics to be discussed include: Cell discovery & structure; cell division; protein synthesis; DNA and RNA biology; gene control; gene expression; Molecular biology techniques.
The laboratories aim to expose students to relevant laboratory techniques, to reinforce molecular and cellular biological concepts introduced in the lectures, and to encourage computer usage in the form of wordprocessing, e-mail, spreadsheets, tables, and graphic presentations.

Students completing this course should be able to:
‚ demonstrate an understanding of fundamental concepts of the structure and cellular processes of prokaryotes and eukaryotes; plus an experimental basis for that understanding
‚ demonstrate structure/function analysis of single molecules to tissue organization in organisms
‚ demonstrate knowledge of gene regulation and expression
‚ demonstrate a working knowledge of general laboratory safety & use of a Material Safety Data Sheets
‚ conduct basic laboratory techniques utilized in cell biology such as centrifugation; protein quantitation; centrifugation; electrophoresis; Western analysis; cloning, expression, and purification of genetically engineered proteins C primarily sharpening analytical and quantitative skills
‚ maintain a laboratory notebook
‚ exercise computer programs to: generate word-processing documents; send/receive e-mails; produce graphic displays of laboratory data; access common sites such as electronic dictionaries

Prerequisite: Successful completion of CHM 130 and 131 are required; successful completion of CHM 250 is recommended.

REQUIRED TEXTBOOK:
' The World of the Cell; Becker, Kleinsmith, and Hardin, Fourth Edition. The text will be necessary for your reading assignments, pictures, diagrams, etc. but most of the exam information will be covered in class notes. The publisher provides a website containing quizzes, essay questions, and related links at www.awlonline.com/becker.

' Laboratory Manual: Purchase of a separate manual is not required since this course is web enhanced. Laboratory protocols will be available at http://courses.uncp.edu/courses/BIO-371-01-F02/. Each student will be responsible for printing a readable copy to bring to lab on a weekly basis. A limited number of copies will be provided by the instructor. Students will need to purchase a 3-ring binder or similar type notebook for laboratory use. Personal safety goggles can be purchased through the UNCP bookstore but are not mandatory.

POLICIES USED IN THIS COURSE:

LABORATORY: Proper laboratory precautions following OSHA guidelines will be stressed. A lab coat and lab notebook will be required of the student. Eye wear and gloves will be provided by the department. A final, written laboratory exam will be given at the end of the semester. The laboratory notebook will be collected and graded, then returned to the student.

EXPECTATIONS: Please note that this is a tentative schedule; deviations will be noted in class. Exams will be announced at least one week in advance. Class participation and discussion is desired.
Class attendance is expected. Excessive cuts will not be tolerated. If you miss a lecture, you are responsible for obtaining missed notes and are relying on the good will of another student. You learn more by doing. Therefore, laboratory ATTENDANCE and PARTICIPATION are a MUST ... More than two lab absences will result in cutting of your final grade the equivalent of one letter grade!!!! Laboratory absences in excess of 4 will result in a grade of AF@ automatically. No make-up laboratories will be offered.
This is a classroom setting; therefore, use of cell phones and beepers will not be allowed.

GRADING: No make-up exams will be offered.....You must take your exam on the scheduled day....... I WILL NOT OFFER THE EXAM ON A LATER DATE !!! Your final grade will be calculated from:
C written exams and final exam (75%) -- exams will be composed of a combination of multiple choice questions, true/false, graphics, and short answer, essay type questions (plus bonus points)
C laboratory participation, written lab notebook, and lab quiz (25%) -- the laboratory quiz will be a combination of written short answer and practical questions.

If you miss a scheduled exam (you must advise me of your absence and reason before the exam and the absence must be approved), the grade earned on the final comprehensive exam will be counted twice.

Grading scale will be typical ten point scale:
A = 94-100 B+ = 86-89 C+ = 76-79 D+ = 66-69 F = <60
A- = 90-93 B = 83-85 C = 73-75 D = 63-65
B- = 80-82 C- =70-72 D- = 60-62

DISABILITY
Any student with a documented disability needing academic adjustments is requested to speak directly to Disability Support Services and the instructor, as early in the semester (preferably within the first class week) as possible. All discussions will remain confidential. This syllabus is available in alternative formats upon request. Please contact Mary Helen Walker,
Disability Support Services, DF Lowry Bldg., 910-521-6695.

Important Dates to Note:
October 9 (Wednesday), 2002 -- mid semester grades are due
October 21 (Monday), 2002 -- is the last day to drop a course with a grade of AW@.
December 6 (Friday ), 2002 -- last day of classes

Fall 2002 Tentative Weekly Schedule
The World of the Cell, Becker etal.

Calendar Date Chapter Topic of Discussion (Tentative)


Aug. 19, 21, 23 1, 2 Introductions; A Preview of the Cell
Aug. 26, 28, 30 2 The Chemistry of the Cell
Sept. 2 LABOR DAY HOLIDAY
Sept. 4, 6 HO Centrifugation, Chromatography, Electrophoresis
Sept. 9, 11, 13 3, 4 The Macromolecules of the Cell; Cell Types
Sept. 16, 18, 20 4 Cells and Organelles; Exam 1
Sept. 23, 25, 27 5, 6 Bioenergetics; Enzymes B Biological Catalysts
Sept. 30, Oct. 2, 4 7, 8 Struct/Function/Chemistry of Cellular Membranes; Receptors
Oct. 7, 9 8, 10 Signaling; Cellular Transport; Exam 2
Oct. 10, 11 FALL BREAK
Oct. 14, 16, 18 13, 14, 15 Glycolysis, Aerobic Respiration, & Photosynthesis
Oct. 21, 23, 25 16 DNA, Chromosomes, and the Nucleus
Oct. 28, 30, Nov.1 16, 17 Genetic Mechanism; DNA Replication; Exam 3
Nov. 4, 6, 8 17, 18 Review of Cell Division = Mitosis & Meiosis
Nov. 11, 13, 15 19 Transcription in Prokaryotes and Eukaryotes
Nov. 18, 20, 22 20 Protein Synthesis and Sorting; Exam 4
Nov. 25, 27 20 Protein Synthesis cont.
Nov. 28, 29 THANKSGIVING HOLIDAY
Dec. 2, 4, 6 21 The Regulation of Gene Expression; What Does the Future Hold?; Personal Interests; Review for exam
Dec. 9-13 FINAL EXAMS [Fri, Dec. 13, 8:00-10:00 am]
Comprehensive final --(see policy section)
Dec. 14 FALL COMMENCEMENT 10:00 am