
Dr. Silvia E. Smith
She/her
Assistant Professor
About
I am a natural scientist interested in using evolutionary theory to test hypotheses regarding the natural history and causality of human infectious and chronic diseases. My interest in human disease is broad and began with my doctoral work at the University of Utah where I studied the coevolutionary relationships among humans and the causative pathogens of tuberculosis and leprosy (genus Mycobacterium), accounting for the previously uncharacterized role of genetic recombination in this genus. I continued the work on human infectious diseases as a postdoctoral fellow studying the mechanisms of plasmid-mediated acquisition of drug-resistance in multidrug-resistant human pathogens.
After my first postdoc, my research shifted to characterizing the molecular mechanisms implicated in chronic and inflammatory human diseases. I completed an additional postdoctoral fellowship at the University of Utah School of Medicine, Ophthalmology Department, where I studied the molecular and genetic bases of age-related macular degeneration. I subsequently worked as a Research Scientist at the University of Utah School of Medicine, Department of Internal Medicine, Pulmonary Division, where I studied the genetic and molecular pathways implicated in interstitial lung disease. Currently, I am the Principal Investigator on two patient-reported outcome studies on Shortness of Breath in People with Dysautonomia and Fatigue, Pain, and Sleep Disturbance in People with Dysautonomia.
I have worked with several undergraduate, graduate, and medical students during the last several years, and I am excited to continue working with highly motivated students who have an interest in understanding the mechanisms implicated in human disease.